癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
CMIP Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q8IY22 |
| Other Accession | A1L3F5, Q9D486, NP_085132.1 |
| Reactivity | Human |
| Predicted | Mouse, Xenopus |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 86331 Da |
| Antigen Region | 735-764 aa |
| Gene ID | 80790 |
|---|---|
| Other Names | C-Maf-inducing protein, c-Mip, Truncated c-Maf-inducing protein, Tc-Mip, CMIP, KIAA1694, TCMIP |
| Target/Specificity | This CMIP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 735-764 amino acids from the C-terminal region of human CMIP. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CMIP Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CMIP |
|---|---|
| Synonyms | KIAA1694, TCMIP |
| Function | Plays a role in T-cell signaling pathway. Isoform 2 may play a role in T-helper 2 (Th2) signaling pathway and seems to represent the first proximal signaling protein that links T-cell receptor-mediated signal to the activation of c-Maf Th2 specific factor. |
| Cellular Location | Nucleus. Cytoplasm. Note=Isoform 2 is translocated to the nucleus and is specifically recruited during minimal change nephrotic syndrome (MCNS) (PubMed:12939343, PubMed:15616553). Detected in nuclear and cytoplasmic compartments during MCNS relapse (PubMed:12939343, PubMed:15616553). Expressed in cytoplasm only during MCNS remission and absent in normal patients (PubMed:12939343) |
| Tissue Location | Isoform 1 is expressed in peripheral blood mononuclear cells and kidney. Lower expression in brain and liver Expression is down-regulated in activated cells. Isoform 2 is expressed in lymphocyte precursors, however, expression shuts down during maturation and differentiation in thymus and fetal liver |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
CMIP plays a role in T-cell signaling pathway. Isoform 2 may play a role in T-helper 2 (Th2) signaling pathway and seems to represent the first proximal signaling protein that links T-cell receptor-mediated signal to the activation of c-Maf Th2 specific factor.
REFERENCES
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Audard, V., et al. Blood 115(18):3756-3762(2010)
Kamal, M., et al. FEBS Lett. 584(3):500-506(2010)
Zhang, S.Y., et al. Sci Signal 3 (122), RA39 (2010) :
Newbury, D.F., et al. Am. J. Hum. Genet. 85(2):264-272(2009)
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