癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Mouse Mast1 Antibody (C-term) 精选
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q9R1L5 |
| Other Accession | Q810W7 |
| Reactivity | Human, Rat, Mouse |
| Predicted | Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 170997 Da |
| Antigen Region | 1438-1464 aa |
| Gene ID | 56527 |
|---|---|
| Other Names | Microtubule-associated serine/threonine-protein kinase 1, Syntrophin-associated serine/threonine-protein kinase, Mast1 {ECO:0000312|MGI:MGI:1861901} |
| Target/Specificity | This Mouse Mast1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1438-1464 amino acids from the C-terminal region of mouse Mast1. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Mouse Mast1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | Mast1 {ECO:0000312|MGI:MGI:1861901} |
|---|---|
| Function | Microtubule-associated protein essential for correct brain development (PubMed:30449657). Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. |
| Cellular Location | Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell projection, axon. Cell projection, dendrite. Note=Also localized in the soma of neurons (PubMed:30449657). Observed as punctate clusters in the processes of interneurons and along the cell body periphery Colocalizes with syntrophins at the cell membrane |
| Tissue Location | Expressed in the brain (PubMed:30449657). Expressed in the developing cortical plate, the intermediate zone and corpus callosal fibers that cross the midline (PubMed:30449657). Detected at low levels in the testis, liver and spleen (PubMed:30449657). Expressed in proximity to neuronal nuclei throughout the cortex and cerebellum, and in the vascular endothelium. Also detected in ependymal cells, the choroid plexus, and in developing spermatid acrosomes |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins.
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¥ 1,250.00
Cat# AP20323b
