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CNTF Antibody (Center) 精选
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, E |
|---|---|
| Primary Accession | P26441 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 22931 Da |
| Antigen Region | 114-140 aa |
| Gene ID | 1270 |
|---|---|
| Other Names | Ciliary neurotrophic factor, CNTF, CNTF |
| Target/Specificity | This CNTF antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 114-140 amino acids from the Central region of human CNTF. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CNTF Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | CNTF (HGNC:2169) |
|---|---|
| Function | Functions as a cytokine through the ciliary neurotrophic factor receptor (CNTFR) complex (PubMed:10966616, PubMed:11285233, PubMed:11294841, PubMed:31932351, PubMed:36930708). The CNTFR complex indeed consists of the membrane-anchored non-signaling receptor CNTFR and the two signaling receptor subunits IL6ST/gp130 and LIFR that transduce the signal into the cell (PubMed:36930708). Functionally, promotes neuronal survival, supports differentiation of various neuronal and non-neuronal cells, and importantly regulates oligodendrocyte progenitor proliferation (PubMed:1861138, PubMed:1883844, PubMed:31932351). Mechanistically, ligand binding to the CNTFR induces dimerization of the IL6ST/gp130 and LIFR, which activates JAK tyrosine kinases (JAK1 or JAK2 and to lesser extent TYK2) bound to their intracellular domains (PubMed:11294841). These kinases subsequently phosphorylate IL6ST/gp130 and LIFR (PubMed:11294841). The tyrosine phosphorylated signaling receptors serve in turn as docking sites for recruitment and activation of signal transducer and activators of transcription (STAT3 and to lesser extent STAT1) (PubMed:11285233, PubMed:11294841). Can also signal via trans-signaling using soluble forms of CNTFR (PubMed:31932351, PubMed:7681218). Seems to prevent the degeneration of motor axons after axotomy (By similarity). |
| Cellular Location | Cytoplasm. Secreted {ECO:0000250|UniProtKB:Q02011}. Note=The precursor semms to be cytoplasmic (Probable). The lack of a specific hydrophobic segment in the precursor sequence suggests that CNTF is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins (By similarity). {ECO:0000250|UniProtKB:P20294, ECO:0000305|PubMed:1915374} |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.
REFERENCES
Masiakowski P., et al. J. Neurochem. 57:1003-1012(1991).
Negro A., et al. Eur. J. Biochem. 201:289-294(1991).
Lam A., et al. Gene 102:271-276(1991).
McDonald J.R., et al. Biochim. Biophys. Acta 1090:70-80(1991).
Takahashi R., et al. Nat. Genet. 7:79-84(1994).
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