癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Rex1 (ZFP42) Antibody (N-term)
Purified Rabbit Polyclonal Antibody (Pab)
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- 文献引用 : 1
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q96MM3 |
| Other Accession | Q8WXE2 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 34802 Da |
| Antigen Region | 1-30 aa |
| Gene ID | 132625 |
|---|---|
| Other Names | Zinc finger protein 42 homolog, Zfp-42, Reduced expression protein 1, REX-1, hREX-1, Zinc finger protein 754, ZFP42, REX1, ZNF754 |
| Target/Specificity | This Rex1 (ZFP42) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human Rex1 (ZFP42). |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Rex1 (ZFP42) Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ZFP42 |
|---|---|
| Synonyms | REX1, ZNF754 |
| Function | Involved in the reprogramming of X-chromosome inactivation during the acquisition of pluripotency. Required for efficient elongation of TSIX, a non-coding RNA antisense to XIST. Binds DXPas34 enhancer within the TSIX promoter. Involved in ES cell self-renewal (By similarity). |
| Cellular Location | Nucleus. |
| Tissue Location | Expressed in kidney, epidermal keratinocytes, prostate epithelial cells, bronchial and small airway lung epithelial cells (at protein level). Expressed in malignant kidney and several carcinoma cell lines (at protein level). Expressed in embryonic stem cells, kidney, epidermal keratinocytes, prostate epithelial cells, bronchial and small airway lung epithelial cells. Expressed in embryonal carcinomas, seminomas, malignant kidney and several carcinoma cell lines. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Zinc finger proteins have regions (zinc finger domains) consisting of cysteines and histidines or cysteines alone which can form a tetrahedral complex around a Zinc ion. Zinc finger represent a class of DNA-binding proteins, act as transcriptional regulators of other genes. These multifunctional transcription factors exhibits control on a large number of cellular genes by binding to sites overlapping the transcription start site and plays an important role in development and differentiation. Hromas et al. in an effort to identify activators of the genetic cascade in hemopoietic differentiation probed a human myeloid cDNA library. ZNF42 may be a regulator of transcriptional events during hemopoietic development.
REFERENCES
Hromas R, et al. J. Biol. Chem. 1991. 266: 14183-14187.
Morris J, et al. Blood 1995. 86: 3640-3647.
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