癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
TCL1A Antibody (Center)
Purified Rabbit Polyclonal Antibody (Pab)
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- 实验流程
- 背景知识
Application 
| WB, FC, E |
|---|---|
| Primary Accession | P56279 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 13460 Da |
| Gene ID | 8115 |
|---|---|
| Other Names | T-cell leukemia/lymphoma protein 1A, Oncogene TCL-1, Oncogene TCL1, Protein p14 TCL1, TCL1A, TCL1 |
| Target/Specificity | This TCL1A antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 32-66 amino acids from the Central region of human TCL1A. |
| Dilution | WB~~1:1000 FC~~1:25 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TCL1A Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TCL1A |
|---|---|
| Synonyms | TCL1 |
| Function | Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of AKT1. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival. |
| Cellular Location | Cytoplasm. Nucleus. Microsome. Endoplasmic reticulum. Note=Microsomal fraction |
| Tissue Location | Restricted in the T-cell lineage to immature thymocytes and activated peripheral lymphocytes. Preferentially expressed early in T- and B-lymphocyte differentiation |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of AKT1. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival.
REFERENCES
Virgilio L.,et al.Proc. Natl. Acad. Sci. U.S.A. 91:12530-12534(1994).
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Fu T.-B.,et al.Cancer Res. 54:6297-6301(1994).
Laine J.,et al.Mol. Cell 6:395-407(2000).
Pekarsky Y.,et al.Proc. Natl. Acad. Sci. U.S.A. 97:3028-3033(2000).
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