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PLAUR Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
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  • 14 - PLAUR Antibody (C-term) AP20579c
    Immunohistochemical analysis of paraffin-embedded H. brain section using PLAUR Antibody (C-term)(Cat#AP20579c). AP20579c was diluted at 1:25 dilution. A peroxidase-conjugated goat anti-rabbit IgG at 1:400 dilution was used as the secondary antibody, followed by DAB staining.
  • 14 - PLAUR Antibody (C-term) AP20579c
    Immunohistochemical analysis of paraffin-embedded H. kidney section using PLAUR Antibody (C-term)(Cat#AP20579c). AP20579c was diluted at 1:25 dilution. A peroxidase-conjugated goat anti-rabbit IgG at 1:400 dilution was used as the secondary antibody, followed by DAB staining.
  • 14 - PLAUR Antibody (C-term) AP20579c
    Immunohistochemical analysis of paraffin-embedded M. brain section using PLAUR Antibody (C-term)(Cat#AP20579c). AP20579c was diluted at 1:25 dilution. A peroxidase-conjugated goat anti-rabbit IgG at 1:400 dilution was used as the secondary antibody, followed by DAB staining.
  • 14 - PLAUR Antibody (C-term) AP20579c
    Immunohistochemical analysis of paraffin-embedded R. brain section using PLAUR Antibody (C-term)(Cat#AP20579c). AP20579c was diluted at 1:25 dilution. A peroxidase-conjugated goat anti-rabbit IgG at 1:400 dilution was used as the secondary antibody, followed by DAB staining.
  • 1 - PLAUR Antibody (C-term) AP20579c
    Western blot analysis of lysates from 293T, A431, Hela, K562, MCF-7 cell line and human brain tissue lysate (from left to right), using PLAUR Antibody (C-term) (Cat. # AP20579c). AP20579c was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysates at 35ug per lane.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC-P, E
Primary Accession Q03405
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 36978 Da
Additional Information
Gene ID 5329
Other Names Urokinase plasminogen activator surface receptor, U-PAR, uPAR, Monocyte activation antigen Mo3, CD87, PLAUR, MO3, UPAR
Target/Specificity This PLAUR antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 273-305 amino acids from the C-terminal region of human PLAUR.
Dilution WB~~1:1000
IHC-P~~1:100~500
E~~Use at an assay dependent concentration.
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPLAUR Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PLAUR
Synonyms MO3, UPAR
Function Acts as a receptor for urokinase plasminogen activator (PubMed:15677461). Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form.
Cellular Location Cell membrane. Cell projection, invadopodium membrane Note=Colocalized with FAP (seprase) preferentially at the cell surface of invadopodia membrane in a cytoskeleton-, integrin- and vitronectin- dependent manner. [Isoform 2]: Secreted {ECO:0000250|UniProtKB:P49616}
Tissue Location Expressed in neurons of the rolandic area of the brain (at protein level). Expressed in the brain
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

BACKGROUND

Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form.

REFERENCES

Roldan A.L.,et al.EMBO J. 9:467-474(1990).
Min H.Y.,et al.J. Immunol. 148:3636-3642(1992).
Bayraktutan U.,et al.Biochem. Soc. Trans. 21:395-395(1993).
Pyke C.,et al.FEBS Lett. 326:69-74(1993).
Casey J.R.,et al.Blood 84:1151-1156(1994).

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