PLAUR Antibody (C-term)
Purified Rabbit Polyclonal Antibody (Pab)
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Application ![]()
| WB, IHC-P, E |
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Primary Accession | Q03405 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 36978 Da |
Gene ID | 5329 |
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Other Names | Urokinase plasminogen activator surface receptor, U-PAR, uPAR, Monocyte activation antigen Mo3, CD87, PLAUR, MO3, UPAR |
Target/Specificity | This PLAUR antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 273-305 amino acids from the C-terminal region of human PLAUR. |
Dilution | WB~~1:1000 IHC-P~~1:100~500 E~~Use at an assay dependent concentration. |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | PLAUR Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | PLAUR |
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Synonyms | MO3, UPAR |
Function | Acts as a receptor for urokinase plasminogen activator (PubMed:15677461). Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. |
Cellular Location | Cell membrane. Cell projection, invadopodium membrane Note=Colocalized with FAP (seprase) preferentially at the cell surface of invadopodia membrane in a cytoskeleton-, integrin- and vitronectin- dependent manner. [Isoform 2]: Secreted {ECO:0000250|UniProtKB:P49616} |
Tissue Location | Expressed in neurons of the rolandic area of the brain (at protein level). Expressed in the brain |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form.
REFERENCES
Roldan A.L.,et al.EMBO J. 9:467-474(1990).
Min H.Y.,et al.J. Immunol. 148:3636-3642(1992).
Bayraktutan U.,et al.Biochem. Soc. Trans. 21:395-395(1993).
Pyke C.,et al.FEBS Lett. 326:69-74(1993).
Casey J.R.,et al.Blood 84:1151-1156(1994).

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