癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
RGS20 Antibody (Center)
Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | O76081 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 43692 Da |
| Gene ID | 8601 |
|---|---|
| Other Names | Regulator of G-protein signaling 20, RGS20, Gz-selective GTPase-activating protein, G(z)GAP, Gz-GAP, Regulator of G-protein signaling Z1, Regulator of Gz-selective protein signaling 1, RGS20, RGSZ1, ZGAP1 |
| Target/Specificity | This RGS20 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 150-184 amino acids from the Central region of human RGS20. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | RGS20 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | RGS20 |
|---|---|
| Synonyms | RGSZ1, ZGAP1 |
| Function | Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)- i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G-protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins (By similarity). |
| Cellular Location | Membrane; Lipid-anchor. Nucleus. Cytoplasm. Note=Shuttles between the cytoplasm/cell membrane and the nucleus Anchored to the membrane through palmitoylation. |
| Tissue Location | Isoform 5 is expressed in brain at high levels in the caudate nucleus and temporal lobe |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)-i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G- protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins (By similarity).
REFERENCES
Wang J.,et al.J. Biol. Chem. 273:26014-26025(1998).
Wang J.,et al.Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases.
Barker S.A.,et al.Genomics 78:223-229(2001).
Puhl H.L. III,et al.Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
Glick J.L.,et al.J. Biol. Chem. 273:26008-26013(1998).
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