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(DANRE) slc17a6a Antibody (C-term)
Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q5W8I7 |
| Reactivity | Zebrafish |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 64461 Da |
| Gene ID | 494492 |
|---|---|
| Other Names | Vesicular glutamate transporter 22, Solute carrier family 17 member 6-A, Vesicular glutamate transporter 2-B, slc17a6a, slc17a6l, vglut22, vglut2b |
| Target/Specificity | This (DANRE) slc17a6a antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 574-607 amino acids DANRE slc17a6a. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | (DANRE) slc17a6a Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | slc17a6a |
|---|---|
| Synonyms | slc17a6l, vglut2.2, vglut2b |
| Function | Multifunctional transporter that transports L-glutamate as well as multiple ions such as chloride, proton, potassium, sodium and phosphate. At the synaptic vesicle membrane, mainly functions as a uniporter which transports preferentially L-glutamate but also, phosphate from the cytoplasm into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. The L-glutamate or phosphate uniporter activity is electrogenic and is driven by the proton electrochemical gradient, mainly by the electrical gradient established by the vacuolar H(+)-ATPase across the synaptic vesicle membrane. In addition, functions as a chloride channel that allows a chloride permeation through the synaptic vesicle membrane therefore affects the proton electrochemical gradient and promotes synaptic vesicles acidification. Moreover, functions as a vesicular K(+)/H(+) antiport allowing to maintain the electrical gradient and to decrease chemical gradient and therefore sustain vesicular L-glutamate uptake. The vesicular H(+)/H(+) antiport activity is electroneutral. At the plasma membrane, following exocytosis, functions as a symporter of Na(+) and phosphate from the extracellular space to the cytoplasm allowing synaptic phosphate homeostasis regulation. The symporter activity is driven by an inside negative membrane potential and is electrogenic (By similarity). Also involved in the regulation of retinal hyaloid vessel regression during postnatal development (By similarity). May also play a role in the endocrine L-glutamatergic system of other tissues such as pineal gland and pancreas (By similarity). |
| Cellular Location | Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Membrane; Multi-pass membrane protein. Synapse, synaptosome Cell membrane {ECO:0000250|UniProtKB:Q8BLE7}; Multi-pass membrane protein |
| Tissue Location | Expressed in spinal cord. |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells (By similarity).
REFERENCES
Higashijima S.,et al.J. Comp. Neurol. 480:1-18(2004).
Yokogawa T.,et al.PLoS Biol. 5:E277-E277(2007).
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Cat# AP20828c
