癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
SOD3 Antibody (C-term) 精选
Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | P08294 |
| Reactivity | Human, Rat |
| Predicted | Bovine, Rabbit |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 25851 Da |
| Gene ID | 6649 |
|---|---|
| Other Names | Extracellular superoxide dismutase [Cu-Zn], EC-SOD, SOD3 |
| Target/Specificity | This SOD3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 186-219 amino acids from the C-terminal region of human SOD3. |
| Dilution | WB~~1:500-1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SOD3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | SOD3 (HGNC:11181) |
|---|---|
| Function | Secreted antioxidant enzyme that acts as the primary scavenger of superoxide radicals in the extracellular space, converting them to hydrogen peroxide and thereby protecting tissues from oxidative damage (PubMed:12933702, PubMed:15761197). Also preserves nitric oxide bioavailability by preventing the formation of harmful peroxynitrite (PubMed:12933702). Stored in intracellular pre-formed vesicles of macrophages and neutrophils and released upon stimulation by inflammatory mediators (PubMed:31326693). |
| Cellular Location | Secreted, extracellular space. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:O09164}. Vesicle Note=99% of SOD3/EC-SOD is anchored to heparan sulfate proteoglycans in the tissue interstitium, and 1% is located in the vasculature in equilibrium between the plasma and the endothelium (PubMed:8546689). In macrophages and neutrophiles, extracellular SOD2 in endocytosed and stored in intracellular vesicles (PubMed:31326693) |
| Tissue Location | Expressed in blood vessels, heart, lung, kidney and placenta. Major SOD isoenzyme in extracellular fluids such as plasma, lymph and synovial fluid (PubMed:7959763). Stored in macrophages intracellular compartments (PubMed:31326693) |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen.
REFERENCES
Hjalmarsson K.,et al.Proc. Natl. Acad. Sci. U.S.A. 84:6340-6344(1987).
Folz R.J.,et al.Genomics 22:162-171(1994).
Halleck A.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Adachi T.,et al.Free Radic. Biol. Med. 13:205-210(1992).
Nozik-Grayck E.,et al.Int. J. Biochem. Cell Biol. 37:2466-2471(2005).
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