癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Mouse Hmga2 Antibody (N-term)
Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | P52927 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 11819 Da |
| Gene ID | 15364 |
|---|---|
| Other Names | High mobility group protein HMGI-C, High mobility group AT-hook protein 2, Hmga2, Hmgic |
| Target/Specificity | This Mouse Hmga2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 26-59 amino acids from the N-terminal region of Mouse Hmga2. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Mouse Hmga2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Hmga2 |
|---|---|
| Synonyms | Hmgic |
| Function | Functions as a transcriptional regulator. Functions in cell cycle regulation through CCNA2. Plays an important role in chromosome condensation during the meiotic G2/M transition of spermatocytes. Plays a role in postnatal myogenesis, is involved in satellite cell activation (PubMed:27446912). Positively regulates IGF2 expression through PLAG1 and in a PLAG1-independent manner (By similarity). |
| Cellular Location | Nucleus. |
| Tissue Location | Expressed in mitotic spermatogonia, meiotic spermatocytes, and postmeiotic round spermatids (at protein level) (PubMed:14668482). Expressed in embryonic myogenic progenitor cells (PubMed:27446912). |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Functions as a transcriptional regulator. Functions in cell cycle regulation through CCNA2. Plays an important role in chromosome condensation during the meiotic G2/M transition of spermatocytes.
REFERENCES
Manfioletti G.,et al.Nucleic Acids Res. 19:6793-6797(1991).
Manfioletti G.,et al.Gene 167:249-253(1995).
Zhou X.,et al.Nucleic Acids Res. 24:4071-4077(1996).
Carninci P.,et al.Science 309:1559-1563(2005).
Di Agostino S.,et al.Mol. Biol. Cell 15:1224-1232(2004).
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