癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
(Mouse) Ctf1 Antibody 精选
Purified Rabbit Polyclonal Antibody (Pab)
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- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q60753 |
| Reactivity | Human, Rat, Mouse |
| Predicted | Canine |
| Host | Rabbit |
| Clonality | polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 21509 Da |
| Gene ID | 13019 |
|---|---|
| Other Names | Cardiotrophin-1, CT-1, Ctf1 |
| Target/Specificity | This Mouse Ctf1 antibody is generated from a rabbit immunized with a recombinant protein. |
| Dilution | WB~~1:2000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | (Mouse) Ctf1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | Ctf1 {ECO:0000312|MGI:MGI:105115} |
|---|---|
| Function | Functions as a cytokine that binds to the LIF receptor complex (PubMed:7738033, PubMed:9030543). The LIF receptor complex indeed consists of two signaling receptor subunits IL6ST/gp130 and LIFR that transduce the signal into the cell (PubMed:7738033, PubMed:9030543). Functionnally, acts as a potent cardiac survival factor, and promotes cardiomyocyte proliferation and hypertrophy (PubMed:7862649, PubMed:8625793, PubMed:9050750). Mechanistically, ligand binding to LIFR, induces heterodimerization with IL6ST/gp130 activating JAK tyrosine kinases (JAK1 or JAK2 and to a lesser extent TYK2) bound to their intracellular domains (PubMed:9030543). These kinases subsequently phosphorylate IL6ST/gp130 and LIFR (PubMed:9030543). The tyrosine phosphorylated signaling receptors serve in turn as docking sites for recruitment and activation of signal transducer and activator of transcription STAT3 (PubMed:9030543). |
| Cellular Location | Secreted {ECO:0000250|UniProtKB:Q16619}. |
| Tissue Location | Highly expressed in heart, skeletal muscle, liver, lung and kidney. Lower levels in testis and brain. No expression in spleen. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor.
REFERENCES
Pennica D.,et al.Proc. Natl. Acad. Sci. U.S.A. 92:1142-1146(1995).
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¥ 1,250.00
Cat# AP21323a
