癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
(DANRE) mc4r Antibody (N-Term) 精选
Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | B0V1P1 |
| Reactivity | Zebrafish |
| Host | Rabbit |
| Clonality | polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 36435 Da |
| Gene ID | 286833 |
|---|---|
| Other Names | Melanocortin receptor 4, MC4-R, mc4r |
| Target/Specificity | This DANRE mc4r antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 25-57 amino acids from the human region of DANRE mc4r. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | (DANRE) mc4r Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | mc4r |
|---|---|
| Function | G protein-coupled receptor that binds melanocyte-stimulating hormones (alpha- and beta-MSH) and corticotropin/ACTH, which are peptide products of the POMC precursor. Plays a central role in energy homeostasis and somatic growth. Upon activation, couples to G(s) protein, stimulating adenylate cyclase and the cAMP-dependent signaling pathway. |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:P32245}; Multi-pass membrane protein. Cell projection, cilium membrane {ECO:0000250|UniProtKB:P32245}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P32245} |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP).
REFERENCES
Ringholm A.,et al.J. Neurochem. 82:6-18(2002).
Logan D.W.,et al.Genomics 81:184-191(2003).
Howe K.,et al.Nature 496:498-503(2013).
Sebag J.A.,et al.Science 341:278-281(2013).
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