癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Mouse Dnmt3b Antibody (Center)
Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | O88509 |
| Reactivity | Mouse |
| Host | Rabbit |
| Clonality | polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 97228 Da |
| Gene ID | 13436 |
|---|---|
| Other Names | DNA (cytosine-5)-methyltransferase 3B, Dnmt3b, DNA methyltransferase MmuIIIB, DNA MTase MmuIIIB, MMmuIIIB, Dnmt3b |
| Target/Specificity | This Mouse Dnmt3b antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 356-390 amino acids from the Central region of Mouse Dnmt3b. |
| Dilution | WB~~1:500 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.05% (V/V) Proclin 300. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Mouse Dnmt3b Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Dnmt3b |
|---|---|
| Function | Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing. In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Functions as a transcriptional corepressor by associating with ZHX1 (By similarity). Required for DUX4 silencing in somatic cells (By similarity). |
| Cellular Location | Nucleus. Note=Accumulates in the major satellite repeats at pericentric heterochromatin |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co- repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing. In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Function as transcriptional corepressor by associating with ZHX1 (By similarity).
REFERENCES
Okano M.,et al.Nat. Genet. 19:219-220(1998).
Yin B.,et al.Zhongguo Yi Xue Ke Xue Yuan Xue Bao 21:431-438(1999).
Okano M.,et al.Cell 99:247-257(1999).
Gowher H.,et al.J. Biol. Chem. 277:20409-20414(2002).
Christophorou M.A.,et al.Nature 507:104-108(2014).
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