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UGT2B4 Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

     
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  • 1 - UGT2B4 Antibody (Center) AP21593c
    Anti-UGT2B4 Antibody (Center)at 1:2000 dilution + human liver lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 61 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession P06133
Reactivity Human
Host Rabbit
Clonality polyclonal
Isotype Rabbit IgG
Calculated MW 60513 Da
Additional Information
Gene ID 7363
Other Names UDP-glucuronosyltransferase 2B4, UDPGT 2B4, HLUG25, Hyodeoxycholic acid-specific UDPGT, UDPGTh-1, UGT2B4, UGT2B11
Target/Specificity This UGT2B4 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 338-370 amino acids from the Central region of human UGT2B4.
Dilution WB~~1:2000
E~~Use at an assay dependent concentration.
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsUGT2B4 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name UGT2B4 (HGNC:12553)
Synonyms UGT2B11
Function UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:18719240, PubMed:23288867). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:18719240, PubMed:23288867). Catalyzes the glucuronidation of the endogenous estrogen hormones such as estradiol and estriol (PubMed:18719240, PubMed:23288867).
Cellular Location Endoplasmic reticulum membrane; Single-pass membrane protein
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

BACKGROUND

UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme is active on polyhydroxylated estrogens (such as estriol, 4-hydroxyestrone and 2-hydroxyestriol) and xenobiotics (such as 4-methylumbelliferone, 1-naphthol, 4- nitrophenol, 2-aminophenol, 4-hydroxybiphenyl and menthol). It is capable of 6 alpha-hydroxyglucuronidation of hyodeoxycholic acid.

REFERENCES

Jackson M.R.,et al.Biochem. J. 242:581-588(1987).
Jin C.-J.,et al.Biochem. Biophys. Res. Commun. 194:496-503(1993).
Levesque E.,et al.Pharmacogenetics 9:207-216(1999).
McKenzie P.I.,et al.Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases.
Riedy M.,et al.Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.

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