癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
SCAF8 Antibody (Center)
Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q9UPN6 |
| Reactivity | Human, Rat, Mouse |
| Host | Rabbit |
| Clonality | polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 140519 Da |
| Gene ID | 22828 |
|---|---|
| Other Names | Protein SCAF8, CDC5L complex-associated protein 7, RNA-binding motif protein 16, SR-related and CTD-associated factor 8, SCAF8, CCAP7, KIAA1116, RBM16 |
| Target/Specificity | This SCAF8 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 520-554 amino acids from the Central region of human SCAF8. |
| Dilution | WB~~1:2000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SCAF8 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SCAF8 {ECO:0000303|PubMed:9528809, ECO:0000312|HGNC:HGNC:20959} |
|---|---|
| Function | Anti-terminator protein required to prevent early mRNA termination during transcription (PubMed:31104839). Together with SCAF4, acts by suppressing the use of early, alternative poly(A) sites, thereby preventing the accumulation of non-functional truncated proteins (PubMed:31104839). Mechanistically, associates with the phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit (POLR2A), and subsequently binds nascent RNA upstream of early polyadenylation sites to prevent premature mRNA transcript cleavage and polyadenylation (PubMed:31104839). Independently of SCAF4, also acts as a positive regulator of transcript elongation (PubMed:31104839). |
| Cellular Location | Nucleus. Nucleus matrix. Note=Detected in granular nuclear foci which correspond to sites of active transcription |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
May play a role in mRNA processing.
REFERENCES
Kikuno R.,et al.DNA Res. 6:197-205(1999).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mungall A.J.,et al.Nature 425:805-811(2003).
Patturajan M.,et al.Mol. Cell. Biol. 18:2406-2415(1998).
Ajuh P.,et al.EMBO J. 19:6569-6581(2000).
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¥ 1,250.00
Cat# AP21643c
