癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
TMPRSS11D Antibody (N-Term)
Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, E |
|---|---|
| Primary Accession | O60235 |
| Reactivity | Human, Rat |
| Host | Rabbit |
| Clonality | polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 46263 Da |
| Gene ID | 9407 |
|---|---|
| Other Names | Transmembrane protease serine 11D, 3421-, Airway trypsin-like protease, Transmembrane protease serine 11D non-catalytic chain, Transmembrane protease serine 11D catalytic chain, TMPRSS11D, HAT |
| Target/Specificity | This TMPRSS11D antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 84-119 amino acids from human TMPRSS11D. |
| Dilution | WB~~1:2000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TMPRSS11D Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TMPRSS11D |
|---|---|
| Synonyms | HAT |
| Function | May play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions. Plays a role in the proteolytic processing of ACE2. Proteolytically cleaves and activates the human coronavirus 229E (HCoV-229E) spike glycoprotein which facilitate virus-cell membrane fusions; spike proteins are synthesized and maintained in precursor intermediate folding states and proteolysis permits the refolding and energy release required to create stable virus-cell linkages and membrane coalescence. Preferentially cleaves the C-terminal side of arginine residues at the P1 position of certain peptides, cleaving Boc-Phe-Ser-Arg-4-methylcoumaryl-7-amide most efficiently and having an optimum pH of 8.6 with this substrate. |
| Cellular Location | Cell membrane; Single-pass type II membrane protein. Note=Activated by cleavage and secreted |
| Tissue Location | Located in the cells of the submucosal serous glands of the bronchi and trachea |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
May play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions. Plays a role in the proteolytic processing of ACE2. Proteolytically cleaves and activates the human coronavirus 229E (HCoV-229E) spike glycoprotein which facilitate virus-cell membrane fusions; spike proteins are synthesized and maintained in precursor intermediate folding states and proteolysis permits the refolding and energy release required to create stable virus-cell linkages and membrane coalescence.
REFERENCES
Yamaoka K.,et al.J. Biol. Chem. 273:11895-11901(1998).
Yasuoka S.,et al.Am. J. Respir. Cell Mol. Biol. 16:300-308(1997).
Bertram S.,et al.J. Virol. 87:6150-6160(2013).
Heurich A.,et al.J. Virol. 88:1293-1307(2014).
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