癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Zebrafish wnt8a Antibody (Center)
Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, E |
|---|---|
| Primary Accession | P51028 |
| Reactivity | Zebrafish |
| Host | Rabbit |
| Clonality | polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 40289 Da |
| Gene ID | 30122 |
|---|---|
| Other Names | Protein Wnt-8a, wnt8a, wnt-8, wnt8 |
| Target/Specificity | This Zebrafish wnt8a antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 135-170 amino acids from the Central region of Zebrafish wnt8a. |
| Dilution | WB~~1:1000-1:2000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Zebrafish wnt8a Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | wnt8a |
|---|---|
| Synonyms | wnt-8, wnt8 |
| Function | Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Required for mesoderm and neural ectoderm patterning during gastrulation (PubMed:11703928). Involved in axis formation during embryonic development, via activation of canonical Wnt/CTNNB1 signaling (PubMed:11703928, PubMed:25371059). May be involved in the specification of the spatial patterns of expression of Gsc and other regulatory genes leading to the establishment of the embryonic axis (PubMed:7600994). |
| Cellular Location | Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:Q9H1J5}. Secreted {ECO:0000250|UniProtKB:Q9H1J5} |
| Tissue Location | Expressed in the margin of the pregastrula embryo destined to be the future mesoderm. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. Is likely to signal over only few cell diameters. May be involved in the specification of the spatial patterns of expression of Gsc and other regulatory genes leading to the establishment of the embryonic axis.
REFERENCES
Kelly G.M.,et al.Development 121:1787-1799(1995).
Lekven A.C.,et al.Dev. Cell 1:103-114(2001).
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