癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
MAZ Antibody (Center)
Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | P56270 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 48608 Da |
| Gene ID | 4150 |
|---|---|
| Other Names | Myc-associated zinc finger protein, MAZI, Pur-1, Purine-binding transcription factor, Serum amyloid A-activating factor-1, SAF-1, Transcription factor Zif87, ZF87, Zinc finger protein 801, MAZ, ZNF801 |
| Target/Specificity | This MAZ antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 295-327 amino acids from the Central region of human MAZ. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | MAZ Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MAZ |
|---|---|
| Synonyms | ZNF801 |
| Function | Transcriptional regulator, potentially with dual roles in transcription initiation and termination. |
| Cellular Location | Nucleus. Note=In brains of Alzheimer disease patients, present in a plaque-like structures |
| Tissue Location | Present in kidney, liver and brain. In the brain, highest levels are found in motor cortex and midfrontal cortex (at protein level). |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
May function as a transcription factor with dual roles in transcription initiation and termination. Binds to two sites, ME1a1 and ME1a2, within the MYC promoter having greater affinity for the former. Also binds to multiple G/C-rich sites within the promoter of the Sp1 family of transcription factors. Regulates inflammation-induced expression of serum amyloid A proteins.
REFERENCES
Bossone S.A.,et al.Proc. Natl. Acad. Sci. U.S.A. 89:7452-7456(1992).
Pyrc J.J.,et al.Biochemistry 31:4102-4110(1992).
Tsutsui H.,et al.Biochem. Biophys. Res. Commun. 226:801-809(1996).
Parks C.L.,et al.J. Biol. Chem. 271:4417-4430(1996).
Song J.,et al.J. Biol. Chem. 273:20603-20614(1998).
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