癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
ANO10 Antibody (C-Term)
Purified Rabbit Polyclonal Antibody (Pab)
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- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q9NW15 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 76329 Da |
| Gene ID | 55129 |
|---|---|
| Other Names | Anoctamin-10, Transmembrane protein 16K, ANO10, TMEM16K |
| Target/Specificity | This ANO10 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 620-653 amino acids from human ANO10. |
| Dilution | WB~~1:1000-2000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ANO10 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ANO10 |
|---|---|
| Synonyms | TMEM16K |
| Function | Does not exhibit calcium-activated chloride channel (CaCC) activity. Can inhibit the activity of ANO1. |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Note=Shows predominantly an intracellular localization with a weak expression in the cell membrane |
| Tissue Location | Highly expressed in the brain. Intermediate levels in the retina and heart and low levels in the placenta, liver, lung, duodenum, kidney, testis and spleen. In brain areas, highest expression in the frontal and occipital cortices and in the cerebellum. Lower expression in the fetal brain than in the adult brain |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Does not exhibit calcium-activated chloride channel (CaCC) activity. Can inhibit the activity of ANO1.
REFERENCES
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Muzny D.M.,et al.Nature 440:1194-1198(2006).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Schreiber R.,et al.J. Biol. Chem. 285:7838-7845(2010).
Duran C.,et al.Acta Pharmacol. Sin. 32:685-692(2011).
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