癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Epsin2 Antibody (N-term)
Purified Rabbit Polyclonal Antibody (Pab)
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- 实验流程
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Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | O95208 |
| Other Accession | Q9Z1Z3, Q8CHU3, O88339, Q80VP1, Q9Y6I3, Q8IYW4 |
| Reactivity | Human, Rat, Mouse |
| Predicted | Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 68482 Da |
| Antigen Region | 6-36 aa |
| Gene ID | 22905 |
|---|---|
| Other Names | Epsin-2, EPS-15-interacting protein 2, EPN2, KIAA1065 |
| Target/Specificity | This Epsin2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 6-36 amino acids from the N-terminal region of human Epsin2. |
| Dilution | WB~~1:1000 IHC-P~~1:100~500 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Epsin2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | EPN2 |
|---|---|
| Synonyms | KIAA1065 |
| Function | Plays a role in the formation of clathrin-coated invaginations and endocytosis. |
| Cellular Location | Cytoplasm. Cytoplasmic vesicle, clathrin-coated vesicle. Note=In punctate structures throughout the cell, associated with clathrin-coated vesicles, and particularly concentrated in the region of the Golgi complex |
| Tissue Location | Highest expression is found in brain. Detected at lower levels in lung and liver. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Epsin2 plays a role in the formation of clathrin-coated invaginations and endocytosis. It binds to EPS15 (via the NPF repeat domain), as well as to AP-2 and clathrin (via the DPW repeat domain). The protein resides in the cytoplasm, in punctate structures throughout the cell, associated with clathrin-coated vesicles, and is particularly concentrated in the region of the Golgi complex. Highest expression is found in brain, with lower levels detected in lung and liver.
REFERENCES
Ota, T., et al., Nat. Genet. 36(1):40-45 (2004).
Kikuno, R., et al., DNA Res. 6(3):197-205 (1999).
Rosenthal, J.A., et al., J. Biol. Chem. 274(48):33959-33965 (1999).
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