癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
NBAS Antibody (N-Term)
Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
Application 
| WB, E |
|---|---|
| Primary Accession | A2RRP1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 268571 Da |
| Gene ID | 51594 |
|---|---|
| Other Names | Neuroblastoma-amplified sequence, Neuroblastoma-amplified gene protein, NBAS, NAG |
| Target/Specificity | This NBAS antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 628-661 amino acids from the human NBAS. |
| Dilution | WB~~1:2000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | NBAS Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NBAS (HGNC:15625) |
|---|---|
| Function | Involved in Golgi-to-endoplasmic reticulum (ER) retrograde transport; the function is proposed to depend on its association in the NRZ complex which is believed to play a role in SNARE assembly at the ER (PubMed:19369418). Required for normal embryonic development (By similarity). May play a role in the nonsense-mediated decay pathway of mRNAs containing premature stop codons (By similarity). |
| Cellular Location | Cytoplasm. Endoplasmic reticulum. Endoplasmic reticulum membrane; Peripheral membrane protein |
| Tissue Location | Broadly expressed, with highest levels in heart and skeletal muscle, and lowest levels in liver, small intestine and thymus. Well expressed in retinal ganglion cells, epidermal skin cells, and leukocytes. Up-regulated together with N-myc in some neuroblastoma cell lines. |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
Scott D.K.,et al.Gene 307:1-11(2003).
Hillier L.W.,et al.Nature 434:724-731(2005).
Wimmer K.,et al.Oncogene 18:233-238(1999).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Fruehwald M.C.,et al.J. Med. Genet. 37:501-509(2000).
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¥ 1,250.00
Cat# AP21918a
