癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
MIB2 Antibody (N-Term) 精选
Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, E |
|---|---|
| Primary Accession | Q96AX9 |
| Reactivity | Human, Mouse |
| Predicted | Rat, Bovine, Canine, Chicken |
| Host | Rabbit |
| Clonality | polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 103658 Da |
| Gene ID | 142678 |
|---|---|
| Other Names | E3 ubiquitin-protein ligase MIB2, 6.3.2.-, Mind bomb homolog 2, Novel zinc finger protein, Novelzin, Putative NF-kappa-B-activating protein 002N, Skeletrophin, Zinc finger ZZ type with ankyrin repeat domain protein 1, MIB2, SKD, ZZANK1 |
| Target/Specificity | This MIB2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 216-249 amino acids from human MIB2. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | MIB2 Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | MIB2 (HGNC:30577) |
|---|---|
| Synonyms | SKD, ZZANK1 |
| Function | E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. |
| Cellular Location | Cytoplasm. Endosome. Note=Colocalizes with endosomal compartments |
| Tissue Location | Expressed in skeletal muscle, and to a lesser extent in heart, brain and kidney. |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors (By similarity).
REFERENCES
Takeuchi T.,et al.Am. J. Pathol. 163:1395-1404(2003).
Takeuchi T.,et al.Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases.
Matsuda A.,et al.Oncogene 22:3307-3318(2003).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Gregory S.G.,et al.Nature 441:315-321(2006).
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