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COXIV Isoform 2 Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - COXIV Isoform 2 Antibody AP22137a
    All lanes : Anti-COXIV Isoform 2 Antibody at 1:2000 dilution Lane 1: HepG2 whole cell lysate Lane 2: MCF-7 whole cell lysate Lane 3: mouse small intestine lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 20 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession Q96KJ9
Reactivity Human, Rat, Mouse
Host Rabbit
Clonality polyclonal
Isotype Rabbit IgG
Calculated MW 20010 Da
Additional Information
Gene ID 84701
Other Names Cytochrome c oxidase subunit 4 isoform 2, mitochondrial, Cytochrome c oxidase subunit IV isoform 2, COX IV-2, COX4I2, COX4L2
Target/Specificity This COXIV Isoform 2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 141-171 amino acids from human COXIV Isoform 2.
Dilution WB~~1:2000
E~~Use at an assay dependent concentration.
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCOXIV Isoform 2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name COX4I2 (HGNC:16232)
Function Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Cellular Location Mitochondrion inner membrane {ECO:0000250|UniProtKB:P00423}; Single-pass membrane protein {ECO:0000250|UniProtKB:P00423}
Tissue Location Highly expressed in lung.
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

BACKGROUND

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

REFERENCES

Huettemann M.,et al.Gene 267:111-123(2001).
Deloukas P.,et al.Nature 414:865-871(2001).
Shteyer E.,et al.Am. J. Hum. Genet. 84:412-417(2009).

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