癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
PLEC Antibody (C-Term)
Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, IF, E |
|---|---|
| Primary Accession | Q15149 |
| Other Accession | Q9JI55, Q9QXS1, P30427 |
| Reactivity | Human, Rat, Mouse |
| Predicted | Mouse, Rat |
| Host | Rabbit |
| Clonality | polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 531791 Da |
| Gene ID | 5339 |
|---|---|
| Other Names | Plectin, PCN, PLTN, Hemidesmosomal protein 1, HD1, Plectin-1, PLEC, PLEC1 |
| Target/Specificity | This PLEC antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 4241-4275 amino acids from human PLEC. |
| Dilution | WB~~1:1000 IF~~1:25 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PLEC Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PLEC |
|---|---|
| Synonyms | PLEC1 |
| Function | Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. |
| Cellular Location | Cytoplasm, cytoskeleton. Cell junction, hemidesmosome. Cell projection, podosome {ECO:0000250|UniProtKB:Q9QXS1}. Note=Localized to the cortex of myotube podosomes. {ECO:0000250|UniProtKB:Q9QXS1} |
| Tissue Location | Widely expressed with highest levels in muscle, heart, placenta and spinal cord |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofibers integrity.
REFERENCES
Liu C.-G.,et al.Proc. Natl. Acad. Sci. U.S.A. 93:4278-4283(1996).
McLean W.H.I.,et al.Genes Dev. 10:1724-1735(1996).
Zhang T.,et al.Genome Res. 14:79-89(2004).
Nusbaum C.,et al.Nature 439:331-335(2006).
Bienvenut W.V.,et al.Submitted (DEC-2008) to UniProtKB.
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