癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
ST8SIA1 Antibody (N-Term)
Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, FC, E |
|---|---|
| Primary Accession | Q92185 |
| Other Accession | P61642 |
| Reactivity | Human, Rat |
| Host | Rabbit |
| Clonality | polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 40519 Da |
| Gene ID | 6489 |
|---|---|
| Other Names | Alpha-N-acetylneuraminide alpha-2, 8-sialyltransferase, 2.4.99.8, Alpha-2, 8-sialyltransferase 8A, Ganglioside GD3 synthase, Ganglioside GT3 synthase, Sialyltransferase 8A, SIAT8-A, Sialyltransferase St8Sia I, ST8SiaI, ST8SIA1, SIAT8, SIAT8A |
| Target/Specificity | This ST8SIA1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 53-84 amino acids from human ST8SIA1. |
| Dilution | WB~~1:1000-1:2000 FC~~1:25 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ST8SIA1 Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ST8SIA1 (HGNC:10869) |
|---|---|
| Synonyms | SIAT8, SIAT8A |
| Function | Catalyzes the addition of sialic acid in alpha 2,8-linkage to the sialic acid moiety of the ganglioside GM3 to form ganglioside GD3; gangliosides are a subfamily of complex glycosphingolipds that contain one or more residues of sialic acid (PubMed:18348864, PubMed:22885356, PubMed:7937974, PubMed:8058740, PubMed:8195250, PubMed:8631981, PubMed:8706663). Can catalyze the addition of a second alpha-2,8-sialic acid to GD3 to form GT3 (PubMed:8631981). Can use GM1b, GD1a and GT1b as acceptor substrates to synthesize GD1c, GT1a and GQ1b respectively (PubMed:8706663). Can synthesize unusual tetra- and pentasialylated lactosylceramide derivatives identified as GQ3 (II3Neu5Ac4-Gg2Cer) and GP3 (II3Neu5Ac5-Gg2Cer) in breast cancer cells (PubMed:22885356). |
| Cellular Location | Golgi apparatus membrane; Single- pass type II membrane protein |
| Tissue Location | Strongly expressed in melanoma cell lines, adult and fetal brain and to a lesser extent in adult and fetal lung |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Involved in the production of gangliosides GD3 and GT3 from GM3; gangliosides are a subfamily of complex glycosphinglolipds that contain one or more residues of sialic acid.
REFERENCES
Sasaki K.,et al.J. Biol. Chem. 269:15950-15956(1994).
Nara K.,et al.Proc. Natl. Acad. Sci. U.S.A. 91:7952-7956(1994).
Haraguchi M.,et al.Proc. Natl. Acad. Sci. U.S.A. 91:10455-10459(1994).
Nakayama J.,et al.J. Biol. Chem. 271:3684-3691(1996).
Rimoldi S.,et al.Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
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