癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
TCIRG1 Antibody (C-Term)
Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, FC, E |
|---|---|
| Primary Accession | Q13488 |
| Reactivity | Human, Mouse |
| Predicted | Human |
| Host | Rabbit |
| Clonality | polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 92968 Da |
| Gene ID | 10312 |
|---|---|
| Other Names | V-type proton ATPase 116 kDa subunit a isoform 3, V-ATPase 116 kDa isoform a3, Osteoclastic proton pump 116 kDa subunit, OC-116 kDa, OC116, T-cell immune regulator 1, T-cell immune response cDNA7 protein, TIRC7, Vacuolar proton translocating ATPase 116 kDa subunit a isoform 3, TCIRG1, ATP6N1C, ATP6V0A3 |
| Target/Specificity | This TCIRG1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 668-702 amino acids from the human region of human TCIRG1. |
| Dilution | WB~~1:2000 FC~~1:25 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TCIRG1 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TCIRG1 |
|---|---|
| Synonyms | ATP6N1C, ATP6V0A3 |
| Function | Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Seems to be directly involved in T-cell activation (PubMed:10329006). |
| Cellular Location | Membrane; Multi-pass membrane protein |
| Tissue Location | Isoform long is highly expressed in osteoclastomas. Isoform short is highly expressed in thymus |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Part of the proton channel of V-ATPases (By similarity). Seems to be directly involved in T-cell activation.
REFERENCES
Li Y.P.,et al.Biochem. Biophys. Res. Commun. 218:813-821(1996).
Utku N.,et al.Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases.
Heinemann T.,et al.Genomics 57:398-406(1999).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Sobacchi C.,et al.Hum. Mol. Genet. 10:1767-1773(2001).
终于等到您。ABCEPTA（百远生物）抗体产品。
点击下方“我要评价 ”按钮提交您的反馈信息，您的反馈和评价是我们最宝贵的财富之一,
我们将在1-3个工作日内处理您的反馈信息。
如有疑问，联系：0512-88856768 tech-china@abcepta.com.
