MAP4K1(Y381) Antibody
Purified Rabbit Polyclonal Antibody (Pab)
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Application ![]()
| WB, E |
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Primary Accession | Q92918 |
Reactivity | Human |
Host | Rabbit |
Clonality | polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 91296 Da |
Gene ID | 11184 |
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Other Names | Mitogen-activated protein kinase kinase kinase kinase 1, 2.7.11.1, Hematopoietic progenitor kinase, MAPK/ERK kinase kinase kinase 1, MEK kinase kinase 1, MEKKK 1, MAP4K1, HPK1 |
Target/Specificity | This MAP4K1(Y381) antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between amino acids from the human region of human MAP4K1(Y381). |
Dilution | WB~~1:2000 E~~Use at an assay dependent concentration. |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | MAP4K1(Y381) Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | MAP4K1 (HGNC:6863) |
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Synonyms | HPK1 |
Function | Serine/threonine-protein kinase, which plays a role in the response to environmental stress (PubMed:24362026). Appears to act upstream of the JUN N-terminal pathway (PubMed:8824585). Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). May play a role in hematopoietic lineage decisions and growth regulation (PubMed:24362026, PubMed:8824585). Together with CLNK, it enhances CD3-triggered activation of T-cells and subsequent IL2 production (By similarity). |
Tissue Location | Expressed primarily in hematopoietic organs, including bone marrow, spleen and thymus. Also expressed at very low levels in lung, kidney, mammary glands and small intestine |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Serine/threonine-protein kinase, which may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in hematopoietic lineage decisions and growth regulation. Able to autophosphorylate.
REFERENCES
Hu M.C.-T.,et al.Genes Dev. 10:2251-2264(1996).
Grimwood J.,et al.Nature 428:529-535(2004).
Oppermann F.S.,et al.Mol. Cell. Proteomics 8:1751-1764(2009).
Mayya V.,et al.Sci. Signal. 2:RA46-RA46(2009).
Burkard T.R.,et al.BMC Syst. Biol. 5:17-17(2011).

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