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FGL1 antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - FGL1 antibody AP22451a
    All lanes: Anti-FGL1 antibody at 1:500 dilution + A549 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary: Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated (ASP1615) at 1/15000 dilution. Observed band size: 36 KDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession Q08830
Reactivity Human
Host Rabbit
Clonality polyclonal
Isotype Rabbit Ig
Calculated MW 36379 Da
Additional Information
Gene ID 2267
Other Names Fibrinogen-like protein 1, HP-041, Hepassocin, HPS, Hepatocyte-derived fibrinogen-related protein 1, HFREP-1, Liver fibrinogen-related protein 1 {ECO:0000303|Ref.3}, LFIRE-1 {ECO:0000303|Ref.3}, FGL1 {ECO:0000303|PubMed:18039467, ECO:0000312|HGNC:HGNC:3695}
Target/Specificity This antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between amino acids from human.
Dilution WB~~1:500
E~~Use at an assay dependent concentration.
Format Purified polyclonal antibody supplied in PBS with 0.05% (V/V) Proclin 300. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsFGL1 antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FGL1 {ECO:0000303|PubMed:18039467, ECO:0000312|HGNC:HGNC:3695}
Function Immune suppressive molecule that inhibits antigen-specific T- cell activation by acting as a major ligand of LAG3 (PubMed:30580966). Responsible for LAG3 T-cell inhibitory function (PubMed:30580966). Binds LAG3 independently from MHC class II (MHC-II) (PubMed:30580966). Secreted by, and promotes growth of, hepatocytes (PubMed:11470158, PubMed:19880967).
Cellular Location Secreted. Note=Secreted in the blood plasma
Tissue Location Under normal conditions, liver-specific.
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

BACKGROUND

Immune suppressive molecule that inhibits antigen-specific T- cell activation by acting as a major ligand of LAG3 (PubMed:30580966). Responsible for LAG3 T-cell inhibitory function (PubMed:30580966). Binds LAG3 independently from MHC class II (MHC-II) (PubMed:30580966). Secreted by, and promotes growth of, hepatocytes (PubMed:11470158, PubMed:19880967).

REFERENCES

Yamamoto T.,et al.Biochem. Biophys. Res. Commun. 193:681-687(1993).
Hara H.,et al.Biochim. Biophys. Acta 1520:45-53(2001).
Yan J.,et al.Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases.
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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