癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
MGAT1 Antibody (N-term)
Purified Rabbit Polyclonal Antibody (Pab)
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- 背景知识
Application 
| IHC-P, E |
|---|---|
| Primary Accession | P26572 |
| Other Accession | NP_002397 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 50878 Da |
| Antigen Region | 16-46 aa |
| Gene ID | 4245 |
|---|---|
| Other Names | Alpha-1, 3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase, N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I, GNT-I, GlcNAc-T I, MGAT1, GGNT1, GLCT1, GLYT1, MGAT |
| Target/Specificity | This MGAT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 16-46 amino acids from the N-terminal region of human MGAT1. |
| Dilution | IHC-P~~1:100~500 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | MGAT1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MGAT1 |
|---|---|
| Synonyms | GGNT1, GLCT1, GLYT1, MGAT |
| Function | Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans. |
| Cellular Location | Golgi apparatus membrane; Single-pass type II membrane protein. Cytoplasm, perinuclear region. Note=Co-localizes with BRI3 isoform 1 at the perinuclear region. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
There are believed to be over 100 different glycosyltransferases involved in the synthesis of protein-bound and lipid-bound oligosaccharides. MGAT1 (UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I) is a medial-Golgi enzyme essential for the synthesis of hybrid and complex N-glycans. The protein, encoded by a single exon, shows typical features of a type II transmembrane protein. The protein is believed to be essential for normal embryogenesis.
REFERENCES
Tan, J., et al., Eur. J. Biochem. 231(2):317-328 (1995).
Kumar, R., et al., Glycobiology 2(4):383-393 (1992).
Hull, E., et al., Biochem. Biophys. Res. Commun. 176(2):608-615 (1991).
Kumar, R., et al., Proc. Natl. Acad. Sci. U.S.A. 87(24):9948-9952 (1990).
Yip, B., et al., Biochem. J. 321 (Pt 2), 465-474 (1997).
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