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>   首页   >   产品   >   一抗   >   精选抗体   >   CBX8 Antibody (C-term)   

CBX8 Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - CBX8 Antibody (C-term) AP2515b
    The anti-CBX8 C-term Pab (Cat. #AP2515b) is used in Western blot to detect CBX8 in mouse kidney tissue lysate.
  • 14 - CBX8 Antibody (C-term) AP2515b
    Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
  • 1 - CBX8 Antibody (C-term) AP2515b
    CBX8 Antibody (Y321) (Cat. #AP2515b) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the CBX8 antibody detected the CBX8 protein (arrow).
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC-P, E
Primary Accession Q9HC52
Other Accession Q9QXV1
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 43396 Da
Additional Information
Gene ID 57332
Other Names Chromobox protein homolog 8, Polycomb 3 homolog, Pc3, hPc3, Rectachrome 1, CBX8, PC3, RC1
Target/Specificity This CBX8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 306-337 amino acids from the C-terminal region of human CBX8.
Dilution WB~~1:1000
IHC-P~~1:100~500
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCBX8 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CBX8
Synonyms PC3, RC1
Function Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.
Cellular Location Nucleus.
Research Areas

BACKGROUND

Chromobox homolog 8 (CBX8 or Pc3) is a member of Drosophila Polycomb group gene family. The polycomb group (PcG) genes are essential for maintenance of appropriate expression patterns of developmental master regulators and thus are essential for proper development. Changes in expression of PcG proteins have been associated with cancer. CBX8 is involved in maintaining the transcriptionally repressive state of genes. It modifies chromatin, rendering it heritably changed in its expressibility. Structurally, CBX4 contains 1 chromo domain, which is 40 to 50 amino acids long.

REFERENCES

Ota, T., et al., Nat. Genet. 36(1):40-45 (2004).
Strausberg, R.L., et al., Proc. Natl. Acad. Sci. U.S.A. 99(26):16899-16903 (2002).
Bardos, J.I., et al., J. Biol. Chem. 275(37):28785-28792 (2000).

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