癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
SULT4A1a/b Antibody (N-term)
Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q9BR01 |
| Other Accession | NP_795343 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 33085 Da |
| Antigen Region | 1-30 aa |
| Gene ID | 25830 |
|---|---|
| Other Names | Sulfotransferase 4A1, ST4A1, 282-, Brain sulfotransferase-like protein, hBR-STL, hBR-STL-1, Nervous system sulfotransferase, NST, SULT4A1, SULTX3 |
| Target/Specificity | This SULT4A1a/b antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human SULT4A1a/b. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SULT4A1a/b Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SULT4A1 |
|---|---|
| Synonyms | SULTX3 |
| Function | Atypical sulfotransferase family member with very low affinity for 3'-phospho-5'-adenylyl sulfate (PAPS) and very low catalytic activity towards L-triiodothyronine, thyroxine, estrone, p- nitrophenol, 2-naphthylamine, and 2-beta-naphthol. May have a role in the metabolism of drugs and neurotransmitters in the CNS. |
| Cellular Location | Cytoplasm. |
| Tissue Location | Highly expressed in the cerebral cortex and frontal lobe, slightly less in the cerebellum, occipital and temporal lobes, relatively low in the medulla and putamen, and lowest in the spinal cord. No expression detected in the pancreas (PubMed:10698717). Highly expressed in fetal brain and occipital lobe, slightly less in the whole brain, frontal lobe, hippocampus, and lung, very low expression in cerebellum, medulla oblongata, temporal lobe, testis, kidney and appendix (PubMed:12039030). |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure(number and length of exons) is similar among family members. SULT4A1 isoforms a and b are selectively expressed in brain tissue. Isoform a is the predominant of the two isoforms of this protein. Isoform b includes an alternate segment, compared to isoform a, that causes a frameshift. The resulting protein (isoform b) has a distinct and shorter C-terminus when compared to isoform a.
REFERENCES
Liyou, N.E., et al., J. Histochem. Cytochem. 51(12):1655-1664 (2003).
Weinshilboum, R.M., et al., FASEB J. 11(1):3-14 (1997).
Glatt, H., et al., Mutat. Res. 482 (1-2), 27-40 (2001).
Sakakibara, Y., et al., Gene 285 (1-2), 39-47 (2002).
Glatt, H., et al., Toxicol. Lett. 112-113, 341-348 (2000).
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