癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
SNRPC Antibody (C-term)
Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IHC-P, FC, E |
|---|---|
| Primary Accession | P09234 |
| Other Accession | D3ZCL3, Q62241, E1C6F0, Q32PA0 |
| Reactivity | Human, Rat, Mouse |
| Predicted | Bovine, Chicken, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 17394 Da |
| Antigen Region | 133-159 aa |
| Gene ID | 6631 |
|---|---|
| Other Names | U1 small nuclear ribonucleoprotein C {ECO:0000255|HAMAP-Rule:MF_03153}, U1 snRNP C {ECO:0000255|HAMAP-Rule:MF_03153}, U1-C {ECO:0000255|HAMAP-Rule:MF_03153}, U1C {ECO:0000255|HAMAP-Rule:MF_03153}, SNRPC {ECO:0000255|HAMAP-Rule:MF_03153} |
| Target/Specificity | This SNRPC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 133-159 amino acids from the C-terminal region of human SNRPC. |
| Dilution | WB~~1:1000 IHC-P~~1:100~500 FC~~1:10~50 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SNRPC Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SNRPC {ECO:0000255|HAMAP-Rule:MF_03153} |
|---|---|
| Function | Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region. |
| Cellular Location | Nucleus {ECO:0000255|HAMAP-Rule:MF_03153, ECO:0000269|PubMed:2136774} |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
SNRPC is associated with snRNP U1.
REFERENCES
Hochleitner,E.O., J. Biol. Chem. 280 (4), 2536-2542 (2005)
Muto,Y., J. Mol. Biol. 341 (1), 185-198 (2004)
Forch,P., EMBO J. 21 (24), 6882-6892 (2002)
Gunnewiek,J.M., Nucleic Acids Res. 23 (23), 4864-4871 (1995)
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