- 文献引用 : 2
|Application ||DB, E|
|Other Accession||Q62925, P53349|
|Calculated MW||164470 Da|
|Other Names||Mitogen-activated protein kinase kinase kinase 1, MAPK/ERK kinase kinase 1, MEK kinase 1, MEKK 1, MAP3K1, MAPKKK1, MEKK, MEKK1|
|Target/Specificity||This MAP3K1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T1400 of human MAP3K1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Phospho-MAP3K1(T1383) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||MAPKKK1, MEKK, MEKK1|
|Function||Component of a protein kinase signal transduction cascade (PubMed:9808624). Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4 (PubMed:9808624). May phosphorylate the MAPK8/JNK1 kinase (PubMed:17761173). Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway (PubMed:9808624).|
Provided below are standard protocols that you may find useful for product applications.
Component of a protein kinase signal transduction cascade. Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4. Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway.
Dasse,E., Leukemia 21 (4), 595-603 (2007)
Yu,F., PLoS Pathog. 3 (3), E44 (2007)
Wu,Y., Oncogene 25 (42), 5787-5800 (2006)