癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Phospho-TSC2(S1387) Antibody
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 文献引用 : 1
- 实验流程
- 背景知识
Application 
| DB, IF, E |
|---|---|
| Primary Accession | P49815 |
| Other Accession | P49816, Q61037 |
| Reactivity | Human |
| Predicted | Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 200608 Da |
| Gene ID | 7249 |
|---|---|
| Other Names | Tuberin, Tuberous sclerosis 2 protein, TSC2, TSC4 |
| Target/Specificity | This TSC2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S1387 of human TSC2. |
| Dilution | DB~~1:500 IF~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Phospho-TSC2(S1387) Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TSC2 |
|---|---|
| Synonyms | TSC4 |
| Function | In complex with TSC1, this tumor suppressor inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (PubMed:12271141, PubMed:28215400). Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:15340059). May also play a role in microtubule-mediated protein transport (By similarity). Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 (By similarity). |
| Cellular Location | Cytoplasm. Membrane; Peripheral membrane protein. Note=At steady state found in association with membranes |
| Tissue Location | Liver, brain, heart, lymphocytes, fibroblasts, biliary epithelium, pancreas, skeletal muscle, kidney, lung and placenta |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Mutations in TSC2 lead to tuberous sclerosis complex. The protein is believed to be a tumor suppressor and is able to specifically stimulate the intrinsic GTPase activity of the Ras-related protein RAP1A and RAB5. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. TSC2 may have a function in vesicular transport, but may also play a role in the regulation of cell growth arrest and in the regulation of transcription mediated by steroid receptors. Interaction between TSC1 and TSC2 may facilitate vesicular docking.
REFERENCES
Li, Y., et al., Mol. Cell. Biol. 24(18):7965-7975 (2004).
Karbowniczek, M., et al., J. Biol. Chem. 279(29):29930-29937 (2004).
Corradetti, M.N., et al., Genes Dev. 18(13):1533-1538 (2004).
Birchenall-Roberts, M.C., et al., J. Biol. Chem. 279(24):25605-25613 (2004).
Lewis, J.C., et al., J. Med. Genet. 41(3):203-207 (2004).
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