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>   首页   >   产品   >   一抗   >   精选抗体   >   磷酸化抗体   >   Phospho-rat BAD(S97) Antibody   

Phospho-rat BAD(S97) Antibody

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • 6 - Phospho-rat BAD(S97) Antibody AP3777p
    Dot blot analysis of Phospho-rat BAD-S97 Antibody Phospho-specific Pab (Cat. #AP3777p) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.6ug per ml.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
DB, E
Primary Accession O35147
Other Accession NP_073189.1
Reactivity Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 22228 Da
Additional Information
Gene ID 64639
Other Names Bcl2-associated agonist of cell death, BAD, Bcl-2-binding component 6, Bcl-xL/Bcl-2-associated death promoter, Bcl2 antagonist of cell death, Bad
Target/Specificity This rat BAD Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S97 of rat BAD.
Dilution DB~~1:500
E~~Use at an assay dependent concentration.
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPhospho-rat BAD(S97) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Bad
Function Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways.
Cellular Location Mitochondrion outer membrane. Cytoplasm {ECO:0000250|UniProtKB:Q61337}. Note=Colocalizes with HIF3A in the cytoplasm. Upon phosphorylation, locates to the cytoplasm {ECO:0000250|UniProtKB:Q61337}
Tissue Location Expressed in all tissues tested, including brain, liver, spleen and heart. In the brain, restricted to epithelial cells of the choroid plexus. Isoform alpha is the more abundant form
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

BACKGROUND

Bad may be involved in induction of programmed cell death [RGD].

REFERENCES

Huang, C., et al. J. Surg. Res. 164 (1), E1-E11 (2010) : Ahn, S., et al. J. Biol. Chem. 284(13):8855-8865(2009) Koh, P.O. Am. J. Chin. Med. 37(5):867-876(2009) Surgucheva, I., et al. J. Biol. Chem. 283(52):36377-36385(2008) Tommasini, I., et al. J. Immunol. 181(8):5637-5645(2008)

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