癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Phospho-TJP2(S978) Antibody
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| DB, E |
|---|---|
| Primary Accession | Q9UDY2 |
| Other Accession | NP_001164101.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 133958 Da |
| Gene ID | 9414 |
|---|---|
| Other Names | Tight junction protein ZO-2, Tight junction protein 2, Zona occludens protein 2, Zonula occludens protein 2, TJP2, X104, ZO2 |
| Target/Specificity | This TJP2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S978 of human TJP2. |
| Dilution | DB~~1:500 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Phospho-TJP2(S978) Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TJP2 (HGNC:11828) |
|---|---|
| Function | Plays a role in tight junctions and adherens junctions (By similarity). Acts as a positive regulator of RANKL-induced osteoclast differentiation, potentially via mediating downstream transcriptional activity (By similarity). |
| Cellular Location | Cell junction, adherens junction {ECO:0000250|UniProtKB:Q9Z0U1}. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, tight junction {ECO:0000250|UniProtKB:Q9Z0U1}. Nucleus. Note=Also nuclear under environmental stress conditions and in migratory endothelial cells and subconfluent epithelial cell cultures. Localizes to tight junctions during initial stages of their formation (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q95168} |
| Tissue Location | This protein is found in epithelial cell junctions. Isoform A1 is abundant in the heart and brain. Detected in brain and skeletal muscle. It is present almost exclusively in normal tissues Isoform C1 is expressed at high level in the kidney, pancreas, heart and placenta. Not detected in brain and skeletal muscle. Found in normal as well as in most neoplastic tissues |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes a zonula occluden that is a member of the membrane-associated guanylate kinase homolog family. The encoded protein functions as a component of the tight junction barrier in epithelial and endothelial cells and is necessary for proper assembly of tight junctions. Mutation in this gene have been identified in patients with hypercholanemia. Alternate splicing results in multiple transcript variants.
REFERENCES
Lechuga, S., et al. Exp. Cell Res. 316(19):3124-3139(2010)
Remue, E., et al. FEBS Lett. 584(19):4175-4180(2010)
Walsh, T., et al. Am. J. Hum. Genet. 87(1):101-109(2010)
Meerschaert, K., et al. Cell. Mol. Life Sci. 66(24):3951-3966(2009)
Fanning, A.S., et al. Ann. N. Y. Acad. Sci. 1165, 113-120 (2009) :
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