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Phospho-HUMAN-PIK3C2B(Y228) Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - Phospho-HUMAN-PIK3C2B(Y228) Antibody AP3903b
    Dot blot analysis of anti-HUMAN-PIK3C2B(Y228) Antibody Phospho-specific Pab (Cat. #AP3903b) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0. 5ug per ml.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession O00750
Reactivity Human, Rat, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 184768 Da
Additional Information
Gene ID 5287
Other Names Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta, PI3K-C2-beta, PtdIns-3-kinase C2 subunit beta, C2-PI3K, Phosphoinositide 3-kinase-C2-beta, PIK3C2B
Target/Specificity This antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 215-250 amino acids from human.
Dilution WB~~1:1000
E~~Use at an assay dependent concentration.
Format Purified polyclonal antibody supplied in PBS with 0.05% (V/V) Proclin 300. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPhospho-HUMAN-PIK3C2B(Y228) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PIK3C2B
Function Phosphorylates PtdIns and PtdIns4P with a preference for PtdIns (PubMed:10805725, PubMed:11533253, PubMed:9830063). Does not phosphorylate PtdIns(4,5)P2 (PubMed:9830063). May be involved in EGF and PDGF signaling cascades (PubMed:10805725).
Cellular Location Microsome. Cell membrane. Cytoplasm, cytosol Nucleus. Endoplasmic reticulum. Note=Found mostly in the microsome, but also in the plasma membrane and cytosol. Nuclear in testis
Tissue Location Expressed in columnar and transitional epithelia, mononuclear cells, and ganglion cells (at protein level). Widely expressed, with highest levels in thymus and placenta and lowest in peripheral blood, skeletal muscle and kidney
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

BACKGROUND

Phosphorylates PtdIns and PtdIns4P with a preference for PtdIns. Does not phosphorylate PtdIns(4,5)P2. May be involved in EGF and PDGF signaling cascades.

REFERENCES

Brown R.A.,et al.Biochem. Biophys. Res. Commun. 233:537-544(1997).
Arcaro A.,et al.J. Biol. Chem. 273:33082-33090(1998).
Gregory S.G.,et al.Nature 441:315-321(2006).
Arcaro A.,et al.Mol. Cell. Biol. 20:3817-3830(2000).
Wheeler M.,et al.Mol. Cell. Biol. 21:6660-6667(2001).

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