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PAQR3 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 文献引用 : 1
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q6TCH7 |
| Other Accession | Q6TCG8 |
| Reactivity | Human |
| Predicted | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 36217 Da |
| Antigen Region | 242-270 aa |
| Gene ID | 152559 |
|---|---|
| Other Names | Progestin and adipoQ receptor family member 3, Progestin and adipoQ receptor family member III, Raf kinase trapping to Golgi, RKTG, PAQR3 |
| Target/Specificity | This PAQR3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 242-270 amino acids from the C-terminal region of human PAQR3. |
| Dilution | WB~~1:500 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.05% (V/V) Proclin 300. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PAQR3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PAQR3 (HGNC:30130) |
|---|---|
| Function | Golgi-scaffold protein which modulates its interactors acitivies by anchoring them to the Golgi apparatus (PubMed:18547165, PubMed:26311497). Functions as a spatial regulator of RAF1 kinase by sequestrating it to the Golgi apparatus (PubMed:18547165). Acts as a positive regulator of cholesterol biosynthesis by mediating the anchoring of the SCAP:SREBP complex in the Golgi apparatus, thereby promoting SCAP:SREBF2 complex formation, potentiating SREBF2 and SREBF1 processing and enhancing lipid synthesis (PubMed:26311497). Also regulates PPARA and PPARG functions by mediating their interaction with E3 ubiquitin ligases, such as STUB1 or HUWE1, leading to their polyubiquitination and proteasome-mediated degradation (By similarity). |
| Cellular Location | Golgi apparatus membrane; Multi-pass membrane protein |
| Tissue Location | Widely expressed in a range of tissues. |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
PAQR3 is function as a spatial regulator of RAF1 kinase by sequestrating it to the Golgi.
REFERENCES
Jiang, Y., et al. Mol. Cell. Biol. 30(1):78-90(2010)
Garitaonandia, I., et al. J. Recept. Signal Transduct. Res. 29(1):67-73(2009)
Luo, X., et al. Biochem. J. 414(3):399-406(2008)
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Cat# AP4717b
