癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
GSDMA Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IHC-P, FC, E |
|---|---|
| Primary Accession | Q96QA5 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 49365 Da |
| Antigen Region | 66-94 aa |
| Gene ID | 284110 |
|---|---|
| Other Names | Gasdermin-A, Gasdermin-1, GSDMA, GSDM, GSDM1 |
| Target/Specificity | This GSDMA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 66-94 amino acids from the N-terminal region of human GSDMA. |
| Dilution | WB~~1:1000 IHC-P~~1:100~500 FC~~1:10~50 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | GSDMA Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GSDMA (HGNC:13311) |
|---|---|
| Function | [Gasdermin-A]: This form constitutes the precursor of the pore-forming protein and acts as a sensor of infection: upon infection by S.pyogenes, specifically cleaved by S.pyogenes effector protein SpeB in epithelial cells, releasing the N-terminal moiety (Gasdermin-A, N- terminal) that binds to membranes and forms pores, triggering pyroptosis. |
| Cellular Location | [Gasdermin-A]: Cytoplasm, perinuclear region. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q5Y4Y6} |
| Tissue Location | Expressed predominantly in the gastrointestinal tract and, at a lower level, in the skin. Also detected in mammary gland. In the gastrointestinal tract, mainly expressed in differentiated cells, including the differentiated cell layer of esophagus and mucus-secreting pit cells of the gastric epithelium Down-regulated in gastric cancer cells. |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
GSDMA induces apoptosis.
REFERENCES
Soranzo, N., et al. Nat. Genet. 41(11):1182-1190(2009)
Saeki, N., et al. Genes Chromosomes Cancer 48(3):261-271(2009)
Tamura, M., et al. Genomics 89(5):618-629(2007)
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Cat# AP4887a
