癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KRT82 Antibody (Center) 精选
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q9NSB4 |
| Other Accession | Q99M74 |
| Reactivity | Human, Mouse |
| Predicted | Rat, Bovine, Canine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 56653 Da |
| Antigen Region | 312-341 aa |
| Gene ID | 3888 |
|---|---|
| Other Names | Keratin, type II cuticular Hb2, Keratin-82, K82, Type II hair keratin Hb2, Type-II keratin Kb22, KRT82, KRTHB2 |
| Target/Specificity | This KRT82 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 312-341 amino acids from the Central region of human KRT82. |
| Dilution | WB~~1:1000 IHC-P~~1:100~500 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | KRT82 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | KRT82 (HGNC:6459) |
|---|---|
| Synonyms | KRTHB2 |
| Function | Structural component of intermediate filaments in the hair follicle. As a type II hair keratin, forms obligate heterodimers with type I hair keratins that assemble into keratin intermediate filaments. Expressed specifically in cuticle-forming cells of the hair shaft during the anagen phase, where it contributes to the formation and structural integrity of the hair cuticle. |
| Cellular Location | Cytoplasm. |
| Tissue Location | Expressed in the hair follicle, specifically in hair shaft cuticle during the anagen phase of the hair cycle |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
KRT82 is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this keratin appears to be a hair cuticle-specific keratin.
REFERENCES
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) Schweizer, J., et al. J. Cell Biol. 174(2):169-174(2006) Rogers, M.A., et al. J. Invest. Dermatol. 124(3):536-544(2005)
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