癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
G3BP2 Antibody
Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB |
|---|---|
| Primary Accession | Q9UN86 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | polyclonal |
| Calculated MW | 54121 Da |
| Gene ID | 9908 |
|---|---|
| Other Names | Ras GTPase-activating protein-binding protein 2, G3BP-2, GAP SH3 domain-binding protein 2, G3BP2, KIAA0660 |
| Dilution | WB~~ 1:500 |
| Format | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.09% (W/V) sodium azide and 50% glycerol. |
| Storage Conditions | -20℃ |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | G3BP2 {ECO:0000303|PubMed:23279204, ECO:0000312|HGNC:HGNC:30291} |
|---|---|
| Function | Scaffold protein that plays an essential role in cytoplasmic stress granule formation which acts as a platform for antiviral signaling (PubMed:23279204, PubMed:32302570, PubMed:32302571, PubMed:32302572). Plays an essential role in stress granule formation (PubMed:27022092, PubMed:32302570, PubMed:32302571, PubMed:32302572, PubMed:35977029). Stress granules are membraneless compartments that store mRNAs and proteins, such as stalled translation pre-initiation complexes, in response to stress (PubMed:32302570, PubMed:32302571, PubMed:32302572). Promotes formation of stress granules phase-separated membraneless compartment by undergoing liquid-liquid phase separation (LLPS) upon unfolded RNA-binding: functions as a molecular switch that triggers RNA-dependent LLPS in response to a rise in intracellular free RNA concentrations (By similarity). |
| Cellular Location | Cytoplasm. Cytoplasm, Stress granule |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Probable scaffold protein that may be involved in mRNA transport (Potential).
REFERENCES
Kennedy D.,et al.Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases.
Ishikawa K.,et al.DNA Res. 5:169-176(1998).
Guitard E.,et al.Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases.
Kennedy D.,et al.Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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