癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Claudin 1 Antibody
Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, IHC |
|---|---|
| Primary Accession | O95832 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | polyclonal |
| Calculated MW | 22744 Da |
| Gene ID | 9076 |
|---|---|
| Other Names | Claudin-1, Senescence-associated epithelial membrane protein, CLDN1, CLD1, SEMP1 |
| Dilution | WB~~1:1000 IHC~~1:50-1:100 |
| Format | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.09% (W/V) sodium azide and 50% glycerol. |
| Storage Conditions | -20℃ |
| Name | CLDN1 |
|---|---|
| Synonyms | CLD1, SEMP1 |
| Function | Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions (PubMed:23407391). |
| Cellular Location | Cell junction, tight junction. Cell membrane; Multi-pass membrane protein. Basolateral cell membrane Note=Associates with CD81 and the CLDN1-CD81 complex localizes to the basolateral cell membrane. |
| Tissue Location | Strongly expressed in liver and kidney. Expressed in heart, brain, spleen, lung and testis. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (By similarity). Acts as a co- receptor for HCV entry into hepatic cells.
REFERENCES
Swisshelm K.L.,et al.Gene 226:285-295(1999).
Mitic L.M.,et al.Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases.
Halford S.,et al.Cytogenet. Cell Genet. 88:217-217(2000).
Kraemer F.,et al.Hum. Genet. 107:249-256(2000).
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
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