癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
AQP4 Antibody
Purified Rabbit Polyclonal Antibody (Pab)
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- 实验流程
- 背景知识
Application 
| WB |
|---|---|
| Primary Accession | P55087 |
| Reactivity | Human, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 34830 Da |
| Gene ID | 361 |
|---|---|
| Other Names | Aquaporin-4, AQP-4, Mercurial-insensitive water channel, MIWC, WCH4, AQP4 |
| Dilution | WB~~ 1:500 |
| Format | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.09% (W/V) sodium azide and 52% glycerol |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | AQP4 |
|---|---|
| Function | Forms a water-specific channel (PubMed:19383790, PubMed:7559426, PubMed:8601457). Plays an important role in brain water homeostasis (PubMed:37143309). It is involved in glymphatic solute transport and is required for a normal rate of water exchange across the blood brain interface. Required for normal levels of cerebrospinal fluid influx into the brain cortex and parenchyma along paravascular spaces that surround penetrating arteries, and for normal drainage of interstitial fluid along paravenous drainage pathways. Thereby, it is required for normal clearance of solutes from the brain interstitial fluid, including soluble beta-amyloid peptides derived from APP. Plays a redundant role in urinary water homeostasis and urinary concentrating ability (By similarity). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Basolateral cell membrane {ECO:0000250|UniProtKB:P55088}; Multi-pass membrane protein. Endosome membrane {ECO:0000250|UniProtKB:P47863}. Cell membrane, sarcolemma; Multi-pass membrane protein. Cell projection {ECO:0000250|UniProtKB:P47863}. Note=Activation of the vasopressin receptor AVPR1A triggers AQP4 phosphorylation at Ser-180 and promotes its internalization from the cell membrane. Detected on brain astrocyte processes and astrocyte endfeet close to capillaries {ECO:0000250|UniProtKB:P47863} |
| Tissue Location | Detected in skeletal muscle (PubMed:29055082). Detected in stomach, along the glandular base region of the fundic gland (at protein level) (PubMed:8601457). Detected in brain, lung and skeletal muscle, and at much lower levels in heart and ovary (PubMed:7559426, PubMed:8601457). |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Forms a water-specific channel. Osmoreceptor which regulates body water balance and mediates water flow within the central nervous system.
REFERENCES
Yang B.,et al.J. Biol. Chem. 270:22907-22913(1995).
Misaka T.,et al.FEBS Lett. 381:208-212(1996).
Lu M.,et al.Proc. Natl. Acad. Sci. U.S.A. 93:10908-10912(1996).
Nusbaum C.,et al.Nature 437:551-555(2005).
Lanciotti A.,et al.Hum. Mol. Genet. 21:2166-2180(2012).
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