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>   首页   >   产品   >   一抗   >   免疫学   >   Complement C6 Antibody   

Complement C6 Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IP, IHC-P
Primary Accession P13671
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 104786 Da
Additional Information
Gene ID 729
Other Names Complement component C6, C6
Dilution WB~~1:1000
IP~~N/A
IHC-P~~N/A
Format 0.01M PBS, pH 7.2, 0.09% (W/V) Sodium azide, Glycerol 50%
StorageStore at -20 °C.Stable for 12 months from date of receipt
Protein Information
Name C6 {ECO:0000303|PubMed:2789218, ECO:0000312|HGNC:HGNC:1339}
Function Component of the membrane attack complex (MAC), a multiprotein complex activated by the complement cascade, which inserts into a target cell membrane and forms a pore, leading to target cell membrane rupture and cell lysis (PubMed:22267737, PubMed:22832194, PubMed:26841837, PubMed:27052168, PubMed:30552328). The MAC is initiated by proteolytic cleavage of C5 into complement C5b in response to the classical, alternative, lectin and GZMK complement pathways (PubMed:30552328). The complement pathways consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system (PubMed:30552328). Together with component C5b, involved in MAC complex assembly: complement C5b and C6 associate with the outer leaflet of target cell membrane, reducing the energy for membrane bending (PubMed:30552328, PubMed:32569291).
Cellular Location Secreted. Target cell membrane; Multi-pass membrane protein. Note=Secreted as soluble protein (PubMed:2808363). Inserts into the cell membrane of target cells (PubMed:30552328, PubMed:31061395)
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

BACKGROUND

Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.

REFERENCES

Haefliger J.-A.,et al.J. Biol. Chem. 264:18041-18051(1989).
Discipio R.G.,et al.J. Biol. Chem. 264:16197-16206(1989).
Hobart M.J.,et al.Biochemistry 32:6198-6205(1993).
Soejima M.,et al.Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases.
Schmutz J.,et al.Nature 431:268-274(2004).

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