癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Complement C9 Antibody
Purified Rabbit Polyclonal Antibody (Pab)
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- 背景知识
Application 
| WB, IHC-P |
|---|---|
| Primary Accession | P02748 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 63173 Da |
| Gene ID | 735 |
|---|---|
| Other Names | Complement component C9, Complement component C9a, Complement component C9b, C9 |
| Target/Specificity | KLH-conjugated synthetic peptide encompassing a sequence within the center region of human Complement C9. The exact sequence is proprietary. |
| Dilution | WB~~1:1000 IHC-P~~N/A |
| Format | 0.01M PBS, pH 7.2, 0.09% (W/V) Sodium azide, Glycerol 50% |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | C9 {ECO:0000303|PubMed:4018030, ECO:0000312|HGNC:HGNC:1358} |
|---|---|
| Function | Pore-forming component of the membrane attack complex (MAC), a multiprotein complex activated by the complement cascade, which inserts into a target cell membrane and forms a pore, leading to target cell membrane rupture and cell lysis (PubMed:22832194, PubMed:26841837, PubMed:26841934, PubMed:27052168, PubMed:30552328, PubMed:6177822, PubMed:9212048, PubMed:9634479). The MAC is initiated by proteolytic cleavage of C5 into complement C5b in response to the classical, alternative, lectin and GZMK complement pathways (PubMed:9212048, PubMed:9634479). The complement pathways consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system (PubMed:9212048, PubMed:9634479). Constitutes the pore-forming subunit of the MAC complex: during MAC assembly, C9 associates with the C5b8 intermediate complex, and polymerizes to complete the pore (PubMed:26841934, PubMed:30111885, PubMed:30552328, PubMed:34752492, PubMed:4055801, PubMed:6177822). |
| Cellular Location | Secreted. Target cell membrane; Multi-pass membrane protein. Note=Secreted as soluble monomer (PubMed:26841934, PubMed:30111885, PubMed:4055801, PubMed:9634479) Oligomerizes at target membranes, forming a pre-pore (PubMed:26841934, PubMed:30111885, PubMed:31061395, PubMed:4055801, PubMed:9634479). A conformation change then leads to the formation of a 100 Angstrom diameter pore (PubMed:26841934, PubMed:30111885, PubMed:31061395, PubMed:4055801, PubMed:9634479). |
| Tissue Location | Plasma (at protein level). |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C9 is the pore-forming subunit of the MAC.
REFERENCES
Stanley K.K.,et al.EMBO J. 4:375-382(1985).
Discipio R.G.,et al.Proc. Natl. Acad. Sci. U.S.A. 81:7298-7302(1984).
Marazziti D.,et al.Biochemistry 27:6529-6534(1988).
Witzel-Schloemp K.,et al.Immunogenetics 48:144-147(1998).
DiScipio R.G.,et al.J. Biol. Chem. 260:14802-14809(1985).
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