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>   首页   >   产品   >   一抗   >   癌症   >   IL-5 Antibody   

IL-5 Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IP, IHC-P
Primary Accession P05113
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 15238 Da
Additional Information
Gene ID 3567
Other Names Interleukin-5, IL-5, B-cell differentiation factor I, Eosinophil differentiation factor, T-cell replacing factor, TRF, IL5
Dilution WB~~1:1000
IP~~N/A
IHC-P~~N/A
Format 0.01M PBS, pH 7.2, 0.09% (W/V) Sodium azide, Glycerol 50%
StorageStore at -20 °C.Stable for 12 months from date of receipt
Protein Information
Name IL5
Function Homodimeric cytokine expressed predominantly by T-lymphocytes and NK cells that plays an important role in the survival, differentiation, and chemotaxis of eosinophils (PubMed:2653458, PubMed:9010276). Also acts on activated and resting B-cells to induce immunoglobulin production, growth, and differentiation (By similarity). Mechanistically, exerts its biological effects through a receptor composed of IL5RA subunit and the cytokine receptor common subunit beta/CSF2RB (PubMed:1495999, PubMed:22528658). Binding to the receptor leads to activation of various kinases including LYN, SYK and JAK2 and thereby propagates signals through the RAS-MAPK and JAK-STAT5 pathways respectively (PubMed:7613138).
Cellular Location Secreted.
Tissue Location Present in peripheral blood mononuclear cells.
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

BACKGROUND

Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells.

REFERENCES

Azuma C.,et al.Nucleic Acids Res. 14:9149-9158(1986).
Tanabe T.,et al.J. Biol. Chem. 262:16580-16584(1987).
Campbell H.D.,et al.Proc. Natl. Acad. Sci. U.S.A. 84:6629-6633(1987).
Yokota T.,et al.Proc. Natl. Acad. Sci. U.S.A. 84:7388-7392(1987).
Honjo T.,et al.Submitted (FEB-1992) to the EMBL/GenBank/DDBJ databases.

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