癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
IL-5 Antibody
Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, IP, IHC-P |
|---|---|
| Primary Accession | P05113 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 15238 Da |
| Gene ID | 3567 |
|---|---|
| Other Names | Interleukin-5, IL-5, B-cell differentiation factor I, Eosinophil differentiation factor, T-cell replacing factor, TRF, IL5 |
| Target/Specificity | KLH-conjugated synthetic peptide encompassing a sequence within the center region of human IL-5. The exact sequence is proprietary. |
| Dilution | WB~~1:1000 IP~~N/A IHC-P~~N/A |
| Format | 0.01M PBS, pH 7.2, 0.09% (W/V) Sodium azide, Glycerol 50% |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | IL5 |
|---|---|
| Function | Homodimeric cytokine expressed predominantly by T-lymphocytes and NK cells that plays an important role in the survival, differentiation, and chemotaxis of eosinophils (PubMed:2653458, PubMed:9010276). Also acts on activated and resting B-cells to induce immunoglobulin production, growth, and differentiation (By similarity). Mechanistically, exerts its biological effects through a receptor composed of IL5RA subunit and the cytokine receptor common subunit beta/CSF2RB (PubMed:1495999, PubMed:22528658). Binding to the receptor leads to activation of various kinases including LYN, SYK and JAK2 and thereby propagates signals through the RAS-MAPK and JAK-STAT5 pathways respectively (PubMed:7613138). |
| Cellular Location | Secreted. |
| Tissue Location | Present in peripheral blood mononuclear cells. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells.
REFERENCES
Azuma C.,et al.Nucleic Acids Res. 14:9149-9158(1986).
Tanabe T.,et al.J. Biol. Chem. 262:16580-16584(1987).
Campbell H.D.,et al.Proc. Natl. Acad. Sci. U.S.A. 84:6629-6633(1987).
Yokota T.,et al.Proc. Natl. Acad. Sci. U.S.A. 84:7388-7392(1987).
Honjo T.,et al.Submitted (FEB-1992) to the EMBL/GenBank/DDBJ databases.
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