癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
IQGAP1 Antibody
Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB |
|---|---|
| Primary Accession | P46940 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 189252 Da |
| Gene ID | 8826 |
|---|---|
| Other Names | Ras GTPase-activating-like protein IQGAP1, p195, IQGAP1, KIAA0051 |
| Dilution | WB~~1:1000 |
| Format | 0.01M PBS, pH 7.2, 0.09% (W/V) Sodium azide, Glycerol 50% |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | IQGAP1 |
|---|---|
| Synonyms | KIAA0051 |
| Function | Plays a crucial role in regulating the dynamics and assembly of the actin cytoskeleton. Recruited to the cell cortex by interaction with ILK which allows it to cooperate with its effector DIAPH1 to locally stabilize microtubules and allow stable insertion of caveolae into the plasma membrane (By similarity). Binds to activated CDC42 but does not stimulate its GTPase activity. Associates with calmodulin. May promote neurite outgrowth (PubMed:15695813). May play a possible role in cell cycle regulation by contributing to cell cycle progression after DNA replication arrest (PubMed:20883816). |
| Cellular Location | Cell membrane. Nucleus. Cytoplasm. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:Q9JKF1}. Apical cell membrane. Basolateral cell membrane {ECO:0000250|UniProtKB:Q9JKF1}. Note=Subcellular distribution is regulated by the cell cycle, nuclear levels increase at G1/S phase (PubMed:20883816). |
| Tissue Location | Expressed in the placenta, lung, and kidney (PubMed:8051149). A lower level expression is seen in the heart, liver, skeletal muscle and pancreas (PubMed:8051149) |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Binds to activated CDC42 but does not stimulate its GTPase activity. It associates with calmodulin. Could serve as an assembly scaffold for the organization of a multimolecular complex that would interface incoming signals to the reorganization of the actin cytoskeleton at the plasma membrane. May promote neurite outgrowth.
REFERENCES
Weissbach L.,et al.J. Biol. Chem. 269:20517-20521(1994).
Nomura N.,et al.DNA Res. 1:223-229(1994).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Bienvenut W.V.,et al.Submitted (MAR-2009) to UniProtKB.
Grohmanova K.,et al.J. Biol. Chem. 279:48495-48504(2004).
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