癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Anti-MLH1 Antibody
- 产品详情
- 实验流程
Application 
| WB, IF/IC |
|---|---|
| Primary Accession | P40692 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 84601 Da |
| Gene ID | 4292 |
|---|---|
| Other Names | COCA2; DNA mismatch repair protein Mlh1; MutL protein homolog 1 |
| Target/Specificity | KLH-conjugated synthetic peptide encompassing a sequence within the center region of human MLH1. The exact sequence is proprietary. |
| Dilution | WB~~WB (1/500 - 1/1000) IF/IC~~N/A |
| Format | Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide. |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | MLH1 |
|---|---|
| Synonyms | COCA2 |
| Function | Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH3) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Heterodimerizes with MLH3 to form MutL gamma which plays a role in meiosis. |
| Cellular Location | Nucleus. Chromosome. Note=Recruited to chromatin in a MCM9- dependent manner. |
| Tissue Location | Colon, lymphocytes, breast, lung, spleen, testis, prostate, thyroid, gall bladder and heart |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
Bronner C.E.,et al.Nature 368:258-261(1994).
Papadopoulos N.,et al.Science 263:1625-1629(1994).
Kolodner R.D.,et al.Cancer Res. 55:242-248(1995).
Han H.-J.,et al.Hum. Mol. Genet. 4:237-242(1995).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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¥ 1,250.00
Cat# AP51343
