癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
NCOR1 Antibody
Purified Rabbit Polyclonal Antibody (Pab)
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- 背景知识
Application 
| WB, ICC, IHC-P |
|---|---|
| Primary Accession | O75376 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 270210 Da |
| Gene ID | 9611 |
|---|---|
| Other Names | Nuclear receptor corepressor 1, N-CoR, N-CoR1, NCOR1, KIAA1047 |
| Target/Specificity | KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human NCOR1. The exact sequence is proprietary. |
| Dilution | WB~~1:1000 ICC~~N/A IHC-P~~N/A |
| Format | 0.01M PBS, pH 7.2, 0.09% (W/V) Sodium azide, Glycerol 50% |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | NCOR1 |
|---|---|
| Synonyms | KIAA1047 |
| Function | Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). |
| Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00624}. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6.
REFERENCES
Wang J.,et al.Proc. Natl. Acad. Sci. U.S.A. 95:10860-10865(1998).
Yu L.,et al.Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases.
Kikuno R.,et al.DNA Res. 6:197-205(1999).
Ohara O.,et al.Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases.
Zody M.C.,et al.Nature 440:1045-1049(2006).
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