cGK 2 Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
Application ![]()
| WB |
---|---|
Primary Accession | Q13237 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 87432 Da |
Gene ID | 5593 |
---|---|
Other Names | cGMP-dependent protein kinase 2, cGK 2, cGK2, cGMP-dependent protein kinase II, cGKII, PRKG2, PRKGR2 |
Dilution | WB~~1:1000 |
Format | 0.01M PBS, pH 7.2, 0.09% (W/V) Sodium azide, Glycerol 50% |
Storage | Store at -20 °C.Stable for 12 months from date of receipt |
Name | PRKG2 |
---|---|
Synonyms | PRKGR2 |
Function | Crucial regulator of intestinal secretion and bone growth. Phosphorylates and activates CFTR on the plasma membrane. Plays a key role in intestinal secretion by regulating cGMP-dependent translocation of CFTR in jejunum (PubMed:33106379). Acts downstream of NMDAR to activate the plasma membrane accumulation of GRIA1/GLUR1 in synapse and increase synaptic plasticity. Phosphorylates GRIA1/GLUR1 at Ser-863 (By similarity). Acts as a regulator of gene expression and activator of the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2 in mechanically stimulated osteoblasts. Under fluid shear stress, mediates ERK activation and subsequent induction of FOS, FOSL1/FRA1, FOSL2/FRA2 and FOSB that play a key role in the osteoblast anabolic response to mechanical stimulation (By similarity). |
Cellular Location | Apical cell membrane; Lipid-anchor |
Tissue Location | Highly concentrated in brain, lung and intestinal mucosa |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
Orstavik S.,et al.Biochem. Biophys. Res. Commun. 220:759-765(1996).
Fujii M.,et al.FEBS Lett. 375:263-267(1995).
Witczak O.,et al.Biochem. Biophys. Res. Commun. 245:113-119(1998).
Vaandrager A.B.,et al.J. Biol. Chem. 271:7025-7029(1996).
Greenman C.,et al.Nature 446:153-158(2007).

终于等到您。ABCEPTA(百远生物)抗体产品。
点击下方“我要评价 ”按钮提交您的反馈信息,您的反馈和评价是我们最宝贵的财富之一,
我们将在1-3个工作日内处理您的反馈信息。
如有疑问,联系:0512-88856768 tech-china@abcepta.com.
¥ 1,500.00
Cat# AP51450