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>   首页   >   产品   >   一抗   >   信号转导   >   cGK 2 Antibody   

cGK 2 Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession Q13237
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 87432 Da
Additional Information
Gene ID 5593
Other Names cGMP-dependent protein kinase 2, cGK 2, cGK2, cGMP-dependent protein kinase II, cGKII, PRKG2, PRKGR2
Dilution WB~~1:1000
Format 0.01M PBS, pH 7.2, 0.09% (W/V) Sodium azide, Glycerol 50%
StorageStore at -20 °C.Stable for 12 months from date of receipt
Protein Information
Name PRKG2
Synonyms PRKGR2
Function Crucial regulator of intestinal secretion and bone growth. Phosphorylates and activates CFTR on the plasma membrane. Plays a key role in intestinal secretion by regulating cGMP-dependent translocation of CFTR in jejunum (PubMed:33106379). Acts downstream of NMDAR to activate the plasma membrane accumulation of GRIA1/GLUR1 in synapse and increase synaptic plasticity. Phosphorylates GRIA1/GLUR1 at Ser-863 (By similarity). Acts as a regulator of gene expression and activator of the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2 in mechanically stimulated osteoblasts. Under fluid shear stress, mediates ERK activation and subsequent induction of FOS, FOSL1/FRA1, FOSL2/FRA2 and FOSB that play a key role in the osteoblast anabolic response to mechanical stimulation (By similarity).
Cellular Location Apical cell membrane; Lipid-anchor
Tissue Location Highly concentrated in brain, lung and intestinal mucosa
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

REFERENCES

Orstavik S.,et al.Biochem. Biophys. Res. Commun. 220:759-765(1996).
Fujii M.,et al.FEBS Lett. 375:263-267(1995).
Witczak O.,et al.Biochem. Biophys. Res. Commun. 245:113-119(1998).
Vaandrager A.B.,et al.J. Biol. Chem. 271:7025-7029(1996).
Greenman C.,et al.Nature 446:153-158(2007).

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